Bartolomucci Lab
University of Minnesota

The Bartolomucci Lab, at the Department of Integrative Biology and Physiology, University of Minnesota, primarily focuses on the molecular mechanisms of obesity and stress-induced pathologies.

We use an integrative approach to animal patho-physiology which combines state-of-the-art in vivo models with cellular models and molecular techniques. Great emphasis is devoted to the face and construct validity of the animal models used for a specific human disease.

Major ongoing research projects in the Lab are:

Biology and pharmacology of VGF-derived peptides.

  • The mechanism of the anti-obesity effect of the VGF-derived peptide TLQP-21.   

  • The role of TLQP-21 and its C3aR1 receptor on central and peripheral regulation of energy balance and obesity.

  • The development of novel pharmacological analogues of TLQP-21. 

Mechanisms of chronic stress-induced aging-associated diseases.

  • The mechanism of stress-induced accumulation of senescent cells. 

  • The long term consequences of chronic social stress on mortality and ageing.

  • Stress-induced exacerbation of genetic and environmentally-induced cardiometabolic diseases.

Postdoctoral position available!

We are recruiting a postdoctoral fellow for an exciting NIH funded project focused on central/peripheral nervous system regulation of energy balance and obesity by VGF and the TLQP-21 neuropeptide. If you are interested please send CV, research statement and a list of references to Alessandro Bartolomucci